Clayton Christensen's 5 keys to improve the probability of successful innovation

1. Disruption (aka The Innovator's Dilemma)
2. Compete against non-consumption
3. Supply chain disruption (i.e., disruption coming from your own suppliers)
4. Target the job, not the customer
5. Catch the tide of decommoditisation

Via his talk at the 2011 Gartner Symposium

Unfortunately he ran out of time in that talk so he doesn't actually describe the 5th key.